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Cat. No.: HY-N19181

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Hancockiamide D

Name: Hancockiamide D
Brand: MedChemExpress
SKU: HY-N19181
Price: 660.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Hancockiamide D is a phenylpropanoid piperazine alkaloid found in the Australian soil fungus Aspergillus hancockii. Hancockiamide D induces cytotoxic activity in cancer cells and shows no activity in fibroblasts. Hancockiamide D can be used for the research of murine myeloma.

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CAS No.: 2758265-37-9
Formule: C₂₀H₂₆N₂O₃
Masse moléculaire:342.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hancockiamide D Chemical Structure

CAS No.: 2758265-37-9

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

In Vitro

Anti-cancerOthers

Anti-cancer

Hancockiamide D exhibits potent cytotoxic activity against mouse myeloma NS-1 cells (MIC = 3.1 μg/mL), while showing no activity against neonatal foreskin fibroblasts^[1].

Others

Hancockiamide D (compound 4) undergoes N-trans-cinnamoylation catalyzed by the single-module nonribosomal peptide synthetase Hkm11 in vitro to produce Hancockiamide A; the cytochrome P450 Hkm5 converts a portion of Hancockiamide D into H^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2758265-37-9
Masse moléculaire 342.44
Formule C₂₀H₂₆N₂O₃
SMILES

C(C1=CC(OC)=C(O)C(OC)=C1)[C@H]2CN[C@@H](CC3=CC=CC=C3)CN2
Structure Classification
- Others
Initial Source
- Microorganism
Aspergillus hancockii
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Li H, et al. Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway. Organic & Biomolecular Chemistry. 2021;19(3):587-595.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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