JAK2-IN-18
JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. JAK2-IN-18 can inhibit JAK-STAT signaling and shows an IC50 of <100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 can inhibit the proliferation of abnormally proliferating myeloid cells and can be used for the research of myeloproliferative disorders, such as essential thrombocythemia.
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- CAS No.: 3108318-77-7
- Formule: C37H36N8O4
- Masse moléculaire:656.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
JAK2 |
STAT5 |
Chemical Information
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CAS No. 3108318-77-7
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Masse moléculaire 656.73
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Formule C37H36N8O4
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SMILES
COC(C(NC1=CC(NC(C2CC2)=O)=NN3C1=NC=C3)=CC=C4)=C4C5=CC(C6(CC6)C7)=C(C=C5)C(N7CC8=CC=CC(C(N(C)C)=O)=N8)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-18 Related Classifications
HY-179687 Related Classifications
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