KOR agonist 1
KOR agonist 1 (Compound 7a) is a selective agonist for opioid receptor, with EC50s of 3.4, 701.2 and 1649 nM, for KOR, MOR and DOR, respectively. KOR agonist 1 binds KOR, MOR and DOR, with Kis of 3.9, 1053 and 4196 nM, respectively. KOR agonist 1 exhibits antinociceptive effect in ICR mouse model (ED50 in hot plate test is 0.3 mg/kg, in abdominal constriction test is 0.2 mg/kg).
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- Formule: C37H42N2O3
- Masse moléculaire:562.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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κ Opioid Receptor/KOR 3.4 nM (EC50) |
μ Opioid Receptor/MOR 701.2 nM (EC50) |
δ Opioid Receptor/DOR 1649 nM (EC50) |
Chemical Information
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Masse moléculaire 562.74
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Formule C37H42N2O3
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SMILES
COC1=C(O2)C([C@]([C@@H]2[C@]3(OC)[C@@H](C4=CC=CC=C4NCC5=CC=CC=C5)C6)(CCN7CC8CC8)[C@@]6(CC3)C7C9)=C9C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KOR agonist 1 Related Classifications
HY-161539 Related Classifications
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