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Cat. No.: HY-182678

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L-731988

L-731988 is an inhibitor targeting HIV-1 integrase. L-731988 inhibits HIV-1 replication by blocking integrase function. L-731988 exhibits ED₅₀ values ranging from 0.5 μM to 3.14 μM against various HIV-1 isolates. L-731988 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.

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CAS No.: 251922-77-7
Formule: C₁₅H₁₂FNO₄
Masse moléculaire:289.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

L-731988 Chemical Structure

CAS No.: 251922-77-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	CC₅₀	10 μM Compound: L-731988	Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay	[PMID: 19026554]

In Vitro

L-731988 (0.5-5.0 μM) suppresses RT activity of HIV-1 primary isolates in PBLs in a dose-dependent manner^[1].
L-731988 inhibits replication of diverse primary HIV-1 isolates in PBLs, with ED₅₀ values ranging from 0.544 to 3.14 μM; most isolates show less-than-twofold differences in susceptibility relative to HIV_LAI, while HIV_92RW009 exhibits a sixfold reduction in susceptibility^[1].
L-731988 inhibits HIV-1 replication in MT-2 cells with ED₅₀ values ranging from 0.505 to 1.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 251922-77-7
Masse moléculaire 289.26
Formule C₁₅H₁₂FNO₄
SMILES

O=C(C(CC(C1=CC=CN1CC2=CC=C(C=C2)F)=O)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Reinke R, et al. Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid. Antimicrob Agents Chemother. 2002 Oct;46(10):3301-3.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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