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Cat. No.: HY-155149

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MAT2A-IN-12

MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC₅₀ of 5 nM. MAT2A Allosteric inhibitor 2 shows nanomolar activity (IC₅₀=5 μM) in the the proliferation assay (MTAP^-/- cell line).

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CAS No.: 631897-75-1
Formule: C₂₀H₁₇NO₃
Masse moléculaire:319.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

MAT2A-IN-12 Chemical Structure

CAS No.: 631897-75-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4.957 μM Compound: 17; STL235627	Antiproliferative activity against MTAP-/- isogenic variant of human HCT-116 cells assessed as inhibition of cell growth by proliferation assay Antiproliferative activity against MTAP-/- isogenic variant of human HCT-116 cells assessed as inhibition of cell growth by proliferation assay	[PMID: 37591318]
HCT-116	IC₅₀	9.23 μM Compound: 17; STL235627	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by proliferation assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by proliferation assay	[PMID: 37591318]

Chemical Information

CAS No. 631897-75-1
Masse moléculaire 319.35
Formule C₂₀H₁₇NO₃
SMILES

CC1=CC(OC2=C3C=C(OC)C=C2)=C3C(C4=CC=C(C)C=C4)=[N+]1[O-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tuomo Kalliokoski, et al. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg Med Chem Lett . 2023 Oct 1;94:129450 [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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