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Cat. No.: HY-188256

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NSC66098

NSC66098 is an RNA-binding agent. NSC66098 binds to expanded CAG repeat RNA containing AA mismatches and inhibits its pathogenic function. NSC66098 protects cells from proteotoxicity induced by polyglutamine aggregates. NSC66098 can be used in research on Huntington's disease and spinocerebellar ataxia.

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CAS No.: 3259-43-6
Formule: C₁₅H₁₁FN₂S
Masse moléculaire:270.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

NSC66098 Chemical Structure

CAS No.: 3259-43-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

In Vitro

NSC66098 binds (5′CAG/3′GAC) x6 RNA with nanomolar affinity in ITC and discriminates against the control 5′CAG/3′GUC duplex RNA with micromolar affinity^[1].
NSC66098 selectively blocks (5′CAG/3′GAC) RNA and inhibits PCR amplification of CAG-repeat DNA, without comparable effects on controls^[1].
NSC66098 protects Cos-7 cells from proteotoxicity induced by polyglutamine aggregates^[1].
NSC66098 (24 h) reduces Thioflavin T fluorescence of protein aggregates in HD-derived GM04281 fibroblasts in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3259-43-6
Masse moléculaire 270.32
Formule C₁₅H₁₁FN₂S
SMILES

FC1=CC=C2N=NC=C(C2=C1)SCC3=CC=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Khan E, et al. Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein. Scientific reports. 2019 Nov 14;9(1):16872.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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