p97-IN-1
p97-IN-1 is an orally active p97 inhibitor (IC50 = 26 nM). p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML).
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- CAS No.: 3007658-96-7
- Formule: C25H26N6O2
- Masse moléculaire:442.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
p97-IN-1 (Compound V12) (0-10 μM, 72 h) can inhibit the proliferation of various tumor cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:RPMI-8226, HCT-116, BXPC-3, SV620, ARP1, H929, MM-15, KMS-11, MV-4-11, Molm-13 and Molm-16 cells
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Concentration:0-10 μM
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Incubation Time:72 h
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Result:Significantly inhibited the proliferation of various tumor cell lines, including RPMI-8226 (IC50 = 0.5 μM), HCT-116 (IC50 = 0.7 μM), BXPC-3 (IC50 = 1.4 μM), SV620 (IC50 = 2.3 μM), ARP1 (IC50 = 2.1 μM), H929 (IC50 = 0.7 μM), KMS-11 (IC50 = 2.1 μM), MV-4-11 (IC50 = 0.4 μM), Molm-13 (IC50 = 1.4 μM) and Molm-1 6(IC50 = 0.4 μM) cells.
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c nude mice (6-8 weeks, 18-22 g) bearing 5×106 Molm-13 cells xenograft tumor[1]
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Dosage:100 mg/kg or 300 mg/kg
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Administration:Oral administration (p.o.); once daily
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Result:Significantly reduced tumor volume.
Did not significantly alter the weight of the mice.
Chemical Information
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CAS No. 3007658-96-7
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Masse moléculaire 442.51
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Formule C25H26N6O2
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SMILES
CONC(C1=CC=CC2=C1C=C(N2C3=NC4=C(C(NCC5=CC=CC=C5)=N3)CCCN4)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p97-IN-1 Related Classifications
HY-174844 Related Classifications
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