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Cat. No.: HY-174844

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p97-IN-1

p97-IN-1 is an orally active p97 inhibitor (IC₅₀ = 26 nM). p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3007658-96-7
Formule: C₂₅H₂₆N₆O₂
Masse moléculaire:442.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

p97-IN-1 Chemical Structure

CAS No.: 3007658-96-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

p97-IN-1 (Compound V12) (0-10 μM, 72 h) can inhibit the proliferation of various tumor cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RPMI-8226, HCT-116, BXPC-3, SV620, ARP1, H929, MM-15, KMS-11, MV-4-11, Molm-13 and Molm-16 cells
Concentration:

0-10 μM
Incubation Time:

72 h
Result:

Significantly inhibited the proliferation of various tumor cell lines, including RPMI-8226 (IC₅₀ = 0.5 μM), HCT-116 (IC₅₀ = 0.7 μM), BXPC-3 (IC₅₀ = 1.4 μM), SV620 (IC₅₀ = 2.3 μM), ARP1 (IC₅₀ = 2.1 μM), H929 (IC₅₀ = 0.7 μM), KMS-11 (IC₅₀ = 2.1 μM), MV-4-11 (IC₅₀ = 0.4 μM), Molm-13 (IC₅₀ = 1.4 μM) and Molm-1 6(IC₅₀ = 0.4 μM) cells.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-t	AUC_0-inf	MRT	T_max
Rat^[1]	1 mg/kg	i.v.	3.13 h	28.2 ng/mL	20.1 ng·h/mL	32.5 ng·h/mL	3.6 h	/
Rat^[1]	10 mg/kg	i.g.	1.15 h	23.4 ng/mL	23.8 ng·h/mL	38.9 ng·h/mL	1.55 h	0.25 h

In Vivo

p97-IN-1 (Compound V12) (100 mg/kg and 300 mg/kg; p.o.; once daily) significantly inhibits tumor growth and no significant toxicity is observed at high doses in the female BALB/c nude mice bearing Molm-13 xenograft tumor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female BALB/c nude mice (6-8 weeks, 18-22 g) bearing 5×10⁶ Molm-13 cells xenograft tumor^[1]
Dosage:

100 mg/kg or 300 mg/kg
Administration:

Oral administration (p.o.); once daily
Result:

Significantly reduced tumor volume.
Did not significantly alter the weight of the mice.

Chemical Information

CAS No. 3007658-96-7
Masse moléculaire 442.51
Formule C₂₅H₂₆N₆O₂
SMILES

CONC(C1=CC=CC2=C1C=C(N2C3=NC4=C(C(NCC5=CC=CC=C5)=N3)CCCN4)C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang X, et al. Design and Synthesis of Novel 5,6,7,8-Tetrahydropyrido[2,3-D]pyrimidine Derivatives as VCP/p97 Inhibitors for the Treatment of Acute Myeloid Leukemia (AML). Drug Des Devel Ther. 2025 May 27;19:4457-4479. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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