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Cat. No.: HY-175887

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Pomalidomide-C9-Br

Pomalidomide-C9-Br is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC EGFR degrader 15 (HY-175839). PROTAC EGFR degrader 15 is a potent EGFR PROTAC degrader with anti-cancer activity.

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CAS No.: 2545963-23-1
Formule: C₂₃H₂₈BrN₃O₅
Masse moléculaire:506.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Pomalidomide-C9-Br Chemical Structure

CAS No.: 2545963-23-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates :

Chemical Information

CAS No. 2545963-23-1
Masse moléculaire 506.39
Formule C₂₃H₂₈BrN₃O₅
SMILES

O=C(N1)CCC(N2C(C(C(NC(CCCCCCCCCBr)=O)=CC=C3)=C3C2=O)=O)C1=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li L, et al. A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation. Bioorg Chem. 2025 Sep;164:108864. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pomalidomide-C9-Br

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Pomalidomide-C9-Br Related Classifications

HY-175887 Related Classifications

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