PLK1
PLK1 is the best-characterized Polo-like kinase and a master mitotic regulator in mammalian cells. Its N-terminal kinase domain phosphorylates substrates bearing primed phosphopeptides that are recognized by the C-terminal polo-box domain, creating a substrate-targeting switch. PLK1 drives centrosome maturation, bipolar spindle assembly, activation of the anaphase-promoting complex, and cytokinesis, and it is degraded in late mitosis. Expression is strictly cell-cycle-dependent, peaking in G2/M, and PLK1 is overexpressed in a wide range of tumors with poor prognosis. Numerous clinical inhibitors, including volasertib and onvansertib, have validated PLK1 as an anticancer target, making recombinant PLK1 a staple for kinase-screening assays.
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PLK1 Protéines Recombinantes (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
