Ro 0437626
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
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- CAS No.: 134362-79-1
- Formule: C27H35N5O4S
- Masse moléculaire:525.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 3 μM (P2X1 receptor)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
>100 μM
Compound: 1
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Inhibitory concentration against human P2X purinoceptor 3 (hP2X3) expressed in CHO-K1 cells
Inhibitory concentration against human P2X purinoceptor 3 (hP2X3) expressed in CHO-K1 cells
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[PMID: 15927468] |
| CHO-K1 | IC50 |
3 μM
Compound: 1
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Inhibitory concentration against human P2X purinoceptor 1 (hP2X1) expressed in CHO-K1 cells
Inhibitory concentration against human P2X purinoceptor 1 (hP2X1) expressed in CHO-K1 cells
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[PMID: 15927468] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rat (urethane-anaesthetized)[3]
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Dosage:1 and 10 μmol/kg
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Administration:I.v.
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Result:Caused a reduction in postinfusion isovolumetric contractions.
Chemical Information
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CAS No. 134362-79-1
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Masse moléculaire 525.66
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Formule C27H35N5O4S
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SMILES
O=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Jaime-Figueroa S, et al. Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. Bioorg Med Chem Lett. 2005;15(13):3292-3295. [Content Brief]
[2]. Harper MT, et al. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry. J Thromb Haemost. 2010;8(7):1604-1613. [Content Brief]
[3]. King BF, et al. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol. 2004;142(3):519-530. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 0437626 Related Classifications
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