Ro 25-1553
Ro 25-1553 is a selective VIP2 receptor (VPAC2 receptor) agonist. Ro 25-1553 exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 can be used for the study of bronchoconstriction.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 159427-08-4
- Formule: C160H258N46O46
- Masse moléculaire:3562.04
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform PACAP Receptor
More
Activité biologique
Description
IC50 & Target
|
VPAC2 receptor |
In Vitro
Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) potently induces complete, concentration-dependent relaxation of isolated guinea pig tracheal smooth muscle strips pre-contracted with Carbachol (HY-B1208). Its pD2 value is 8.57 when the pre-contraction concentration of Carbachol is 0.1 μmol l-1, and 7.69 when the pre-contraction concentration of Carbachol is 1.0 μmol l-1[1].
Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) exerts an additive effect with Formoterol to relax isolated guinea pig tracheal smooth muscle strips pre-contracted by 0.1 μmol l-1 Carbachol[1].
Ro 25-1553 (1×10-10 to 1×10-4 mol l-1) potently and completely inhibits vagus nerve-induced contractions in isolated guinea pig tracheal preparations; the pD2 value is 8.31 when administered extraluminally and 6.32 when administered intraluminally[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
CAS No. 159427-08-4
-
Masse moléculaire 3562.04
-
Formule C160H258N46O46
-
Sequence
Ac-His-Ser-Asp-Ala-Val-Phe-Thr-Glu-Asn-Tyr-Thr-Lys-Leu-Arg-Lys-Gln-{Nle}-Ala-Ala-Lys-Lys-Tyr-Leu-Asn-Asp-Leu-Lys-Lys-Gly-Gly-Thr-NH2 (Lactam bridge:Lys21-Asp25)
-
Sequence Shortening
Ac-HSDAVFTENYTKLRKQ-{Nle}-AAKKYLNDLKKGGT-NH2 (Lactam bridge:Lys21-Asp25)
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
-
Fiche technique (260 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 25-1553 Related Classifications
HY-P10768 Related Classifications
Powered by Bioz