SHP2-IN-29
SHP2-IN-29 (Compound 3) is a potent SHP2 inhibitor with an IC50 value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against PTP1B and TCPTP, with IC50 values of 4.27 and 4.74 μM, respectively.
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- CAS No.: 2130080-86-1
- Formule: C16H20O4
- Masse moléculaire:276.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
9.9 μM
Compound: 13
|
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS-stimulation and measured after 12 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS-stimulation and measured after 12 hrs by Griess assay
|
[PMID: 31012585] |
Chemical Information
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CAS No. 2130080-86-1
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Masse moléculaire 276.33
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Formule C16H20O4
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SMILES
O=C(O)C1=C(CC/C=C/C=C/CCC)C=C(O)C=C1O
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Structure Classification
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Initial Source
fungal strain F10Z1082
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)