Sozinibercept
Based on 1 Customer Validation
Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats.
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- Pureté : 98.52%
- CAS No.: 2568358-31-4
- Masse moléculaire:120.85 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
IC50 & Target
In Vivo
Sozinibercept (intravitreal injection; once every 4 wk for 4 months) shows selective inhibition of VEGF-C/D, and inhibits diabetic retinal edema induced by streptozotocin (STZ) in the rat model, and equivalent to inhibition of VEGF-A inhibitor (Aflibercept)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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[FLT4 (fms related receptor tyrosine kinase 4, vascular endothelial growth factor receptor 3, VEGFR3, PCL, VEGFR-3)fragment (1-305, containing the immunoglobulin-like C2-type domains 1, 2 and 3)]2-IGHG1 Fc (Fragment constant)
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2568358-31-4
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Appearance Liquid
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Masse moléculaire 120.85 kDa
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Color Colorless to light yellow
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SMILES
[Sozinibercept]
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Synonyms
OPT 302; VGX-300
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (258 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)