Terizidone
Based on 1 Customer Validation
Terizidone is an antibacterial agent. Terizidone acts as a prodrug to release D-cycloserine (HY-B0030), which competitively inhibits alanine racemase and D-alanine:D-alanine ligase, interfering with peptidoglycan synthesis and thereby inhibiting cell wall assembly in Mycobacterium tuberculosis. Terizidone does not significantly inhibit human liver microsomal CYP1A2 or CYP2C9 enzyme activity. Terizidone can be used in research related to tuberculosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.05%
- CAS No.: 25683-71-0
- Formule: C14H14N4O4
- Masse moléculaire:302.29
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Terizidone is a prodrug obtained by condensation of two molecules of cycloserine with one molecule of terephthalaldehyde; the active component D-cycloserine (HY-B0030) is a D-alanine analog that competitively inhibits alanine racemase and D-alanine:D-alanine ligase[1].
Terizidone does not inhibit CYP1A2-dependent Phenacetin (HY-B0476) O-deethylation or CYP2C9-dependent Diclofenac (HY-15036) 4'-hydroxylation in human liver microsomes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 25683-71-0
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Appearance Solid
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Masse moléculaire 302.29
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Formule C14H14N4O4
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Color White to off-white
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SMILES
O=C1NOCC1/N=C/C2=CC=C(/C=N/C3C(NOC3)=O)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvant et solubilité
In Vitro:
0.5 M NaOH : 25 mg/mL (82.70 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.5 M NaOH | 1 mM | 3.3081 mL | 16.5404 mL | 33.0808 mL | 82.7020 mL |
| 5 mM | 0.6616 mL | 3.3081 mL | 6.6162 mL | 16.5404 mL | |
| 10 mM | 0.3308 mL | 1.6540 mL | 3.3081 mL | 8.2702 mL | |
| 15 mM | 0.2205 mL | 1.1027 mL | 2.2054 mL | 5.5135 mL | |
| 20 mM | 0.1654 mL | 0.8270 mL | 1.6540 mL | 4.1351 mL | |
| 25 mM | 0.1323 mL | 0.6616 mL | 1.3232 mL | 3.3081 mL | |
| 30 mM | 0.1103 mL | 0.5513 mL | 1.1027 mL | 2.7567 mL | |
| 40 mM | 0.0827 mL | 0.4135 mL | 0.8270 mL | 2.0676 mL | |
| 50 mM | 0.0662 mL | 0.3308 mL | 0.6616 mL | 1.6540 mL | |
| 60 mM | 0.0551 mL | 0.2757 mL | 0.5513 mL | 1.3784 mL | |
| 80 mM | 0.0414 mL | 0.2068 mL | 0.4135 mL | 1.0338 mL |
Terizidone Related Classifications
HY-112324 Related Classifications
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