Tricin-d6
Tricin-d6 is the deuterium labeled Tricin. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.
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- CAS No.: 1178549-27-3
- Formule: C17H8D6O7
- Masse moléculaire:336.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1178549-27-3
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Unlabeled Cas 520-32-1
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Masse moléculaire 336.33
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Formule C17H8D6O7
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SMILES
O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(OC([2H])([2H])[2H])=C(C(OC([2H])([2H])[2H])=C3)O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Itoh A, et al. Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus. Microbiol Immunol. 2018 May;62(5):341-347. [Content Brief]
[3]. Sadanari H, et al. The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. FEBS Open Bio. 2018 Feb 208(4):646-654. [Content Brief]
[4]. Chung DJ, et al. Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7. J Agric Food Chem. 2018 Jul 566(26):6708-6716. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tricin-d6 Related Classifications
HY-N1127S Related Classifications
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