country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182672

Copy Link Print Information

VT101

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 65194-64-1
Formule: C₁₄H₂₀N₂O₄S
Masse moléculaire:312.38

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VT101 Chemical Structure

CAS No.: 65194-64-1

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research^[1].

IC₅₀ & Target

^[1]

TEAD

454 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform YAP :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H2052	IC₅₀	3 μM Compound: 39; VT101	Antiproliferative activity against human NCI-H2052 cells Antiproliferative activity against human NCI-H2052 cells	[PMID: 39047607]

In Vitro

VT101 inhibits YAP-mediated transcriptional activity with an IC₅₀ of 454 nM in a luciferase reporter assay but does not significantly inhibit the growth of NCI-H2052 cells (IC₅₀ > 3 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 65194-64-1
Masse moléculaire 312.38
Formule C₁₄H₂₀N₂O₄S
SMILES

O=C(C1=CC(S(=O)(N)=O)=CC=C1NC2CCCCC2)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lou J, et al. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities. Eur J Med Chem. 2022;243:114684. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis