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Cat. No.: HY-120376

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XZH-5

XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability.

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CAS No.: 1360562-98-6
Formule: C₂₂H₂₅F₆N₅O₄
Masse moléculaire:537.46

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

XZH-5 Chemical Structure

CAS No.: 1360562-98-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HPAC	IC₅₀	17.4 μM Compound: 1a	Cytotoxicity against human HPAC cells after 72 hrs by MTT assay Cytotoxicity against human HPAC cells after 72 hrs by MTT assay	[PMID: 25698618]
MDA-MB-231	IC₅₀	15.5 μM Compound: 1a	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 25698618]
PANC-1	IC₅₀	24.7 μM Compound: 1a	Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay	[PMID: 25698618]
SW1990	IC₅₀	17.9 μM Compound: 1a	Cytotoxicity against human SW1990 cells after 72 hrs by MTT assay Cytotoxicity against human SW1990 cells after 72 hrs by MTT assay	[PMID: 25698618]

Chemical Information

CAS No. 1360562-98-6
Masse moléculaire 537.46
Formule C₂₂H₂₅F₆N₅O₄
SMILES

O=C(OC)[C@H](CC1=CN(C)C=N1)NC([C@H](C(C)C)NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li Chenglong, et al. Compound XZH-5 inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human hepatocellular carcinoma cells. World Intellectual Property Organization, WO2012078982 A2 2012-06-14

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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XZH-5

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