Z3405279217
Z3405279217 is an inhibitor of ALDH1A3 and ALDH1A1, with an IC50 value of 12.9 μM against ALDH1A3. Z3405279217 can be used in studies of non-small cell lung cancer and glioblastoma.
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- CAS No.: 2305402-77-9
- Formule: C10H8N2OS2
- Masse moléculaire:236.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
ALDH1A3 12.9 μM (IC50) |
ALDH1A1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
16.6 μM
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Reduction of cell viability in human non-small cell lung cancer A549 cells after 24 h incubation.
Reduction of cell viability in human non-small cell lung cancer A549 cells after 24 h incubation.
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2026.07.14.738401v1.abstract |
| A549 | EC50 |
16.4 μM
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Reduction of cell viability in human non-small cell lung cancer A549 cells after 48 h incubation.
Reduction of cell viability in human non-small cell lung cancer A549 cells after 48 h incubation.
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2026.07.14.738401v1.abstract |
| A549 | EC50 |
20.3 μM
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Reduction of cell viability in human non-small cell lung cancer A549 cells after 72 h incubation.
Reduction of cell viability in human non-small cell lung cancer A549 cells after 72 h incubation.
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2026.07.14.738401v1.abstract |
| A 172 | EC50 |
17.7 μM
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Reduction of cell viability in human glioblastoma A172 cells after 24 h incubation.
Reduction of cell viability in human glioblastoma A172 cells after 24 h incubation.
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2026.07.14.738401v1.abstract |
| A 172 | EC50 |
16.6 μM
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Reduction of cell viability in human glioblastoma A172 cells after 48 h incubation.
Reduction of cell viability in human glioblastoma A172 cells after 48 h incubation.
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2026.07.14.738401v1.abstract |
| A 172 | EC50 |
12.3 μM
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Reduction of cell viability in human glioblastoma A172 cells after 72 h incubation.
Reduction of cell viability in human glioblastoma A172 cells after 72 h incubation.
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2026.07.14.738401v1.abstract |
In Vitro
Z3405279217 is a time-dependent covalent inhibitor of the dehydrogenase activity of recombinant ALDH1A3 and ALDH1A1, with kinact/Ki values of 6,200 M-1·min-1 and 11,400 M-1·min-1, respectively[1].
Z3405279217 (20 min) potently inhibits endogenous ALDH activity in non-small cell lung cancer A549 cell extracts and glioblastoma A172 cell extracts, with IC50 values of 0.135 μM and 1.93 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human non-small cell lung cancer A549 cells, human glioblastoma A172 cells
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Concentration:12.3 μM, 16.4 μM, 16.6 μM, 17.7 μM, 20.3 μM (EC50 values)
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Incubation Time:24 h, 48 h, 72 h
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Result:Reduced viability of A549 cells with EC50 values of 16.6 μM (24 h), 16.4 μM (48 h), and 20.3 μM (72 h).
Reduced viability of A172 cells with EC50 values of 17.7 μM (24 h), 16.6 μM (48 h), and 12.3 μM (72 h).
Chemical Information
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CAS No. 2305402-77-9
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Masse moléculaire 236.31
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Formule C10H8N2OS2
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SMILES
C=CC(NC1=NC(C2=CC=CS2)=CS1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z3405279217 Related Classifications
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