1. Apoptosis
  2. Apoptosis
  3. Cadein1

Cadein1 

Cat. No.: HY-131143
Handling Instructions

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53.

For research use only. We do not sell to patients.

Cadein1 Chemical Structure

Cadein1 Chemical Structure

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Description

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

In Vitro

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

Molecular Weight

655.64

Formula

C₃₃H₄₈F₂INO₂

SMILES

COC1=C(C=C2C(CCCCCCCCCCCCCCC)=[N+](CCC2=C1)CC3=C(C=CC=C3F)F)OC.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cadein1Cadein 1Cadein-1ApoptosisG2/Mdelayp53HCT116coloncancerSW620p38Inhibitorinhibitorinhibit

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