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Cat. No.: HY-P99493

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Cantuzumab ravtansine

(Synonyms: IMGN242; huC242-DM4)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Cantuzumab ravtansine (IMGN242; huC242-DM4), an ADC, is a humanized monoclonal antibody, huC242, covalently linked via a disulfide bond to DM4 (HY-12454). Cantuzumab ravtansine has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts.

For research use only. We do not sell to patients.

Purity: 98.71%
CAS No.: 868747-45-9
Molecular Weight:150000 (average)

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Please store the product under the recommended conditions in the Certificate of Analysis.

Cantuzumab ravtansine Chemical Structure

CAS No.: 868747-45-9

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Biological Activity
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- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
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Biological Activity

Description

In Vitro

Cantuzumab ravtansine (huC242-DM4; 5 days) shows cytotoxic effect in CanAg-positive SNU16 gastric cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cantuzumab ravtansine (huC242-DM4; i.v; 3.4 mg/kg; a single dose) causes complete regression of the tumors in SCID mice bearing N87 human gastric tumor xenografts, with significant tumor regression observed at a dose below 2 mg/kg^[1].
Cantuzumab ravtansine (huC242-DM4) is also curative in mice bearing human colon tumor xenografts of HT29 and COLO 205 cells, at doses that were non-toxic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 868747-45-9
Appearance Liquid
Molecular Weight 150000 (average)
Color Colorless to light yellow
SMILES

[Cantuzumab ravtansine]
Synonyms

IMGN242; huC242-DM4
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Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Anal Chem

Bottom-Up Protein Analysis Workflow for Simultaneous Characterization of Payloads, Disulfide Bonds, and Free Thiols in Antibody-Drug Conjugates. [Abstract]

2025 Dec 30;97(51):28132-28138. PMID: 41400128

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (251 KB)
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- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robert J. Lutz, et al. HuC242-DM4, an antibody-maytansinoid conjugate with superior preclinical activity in human CanAg-positive tumor xenograft models in SCID mice. Cancer Res (2005) 65 (9_Supplement): 334-335.

[2]. Olga Ab, et al. Activity of huC242-DM4, an antibody-cytotoxic agent conjugate, used in combination with anti-neoplastic agents against gastric cancer cells in culture. Mol Cancer Ther (2007) 6 (11_Supplement): A127.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Cantuzumab ravtansine

1 Cited Publications

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Biological Activity
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- Clinical Trial
Chemical Information
Publications (1)
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Cantuzumab ravtansine

Publications Citing Use of MedChemExpress (MCE) Cantuzumab ravtansine

Biological Activity

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Publications (1)

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Cantuzumab ravtansine Related Classifications

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