Carbaryl-d7
Based on 1 Customer Validation
Carbaryl-d7 is the deuterium labeled Carbaryl (HY-B1315). Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide.
For research use only. We do not sell to patients.
- Purity : 99%
- CAS No.: 362049-56-7
- Formula: C12H4D7NO2
- Molecular Weight:208.26
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-B2046S
Simazine-d10Stable Isotope -
HY-B1198S
Piperonyl butoxide-d9Stable Isotope -
HY-D0195S
Acesulfame-d4 potassiumStable Isotope -
HY-B0843AS
Metalaxyl-M-d6Fungicide -
HY-B0850S
Difenoconazole-d6 hydrochlorideStable Isotope -
HY-118896S
Acequinocyl-d25Stable Isotope -
HY-N10653
AltemicidinMonoterpene Alkaloid
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 362049-56-7
-
Unlabeled CAS 63-25-2
-
Appearance Solid
-
Molecular Weight 208.26
-
Formula C12H4D7NO2
-
Color White to off-white
-
SMILES
CNC(OC1=C([2H])C([2H])=C([2H])C2=C1C([2H])=C([2H])C([2H])=C2[2H])=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
-
Neurotoxicity Study
This protocol assesses in vitro neurotoxicity by combining neuronal viability, mitochondrial/metabolic activity, neurite outgrowth, and optional neuronal network function readouts. Calcein-AM or resazurin/PrestoBlue readouts estimate viable or metabolically active cells; βIII-tubulin immunofluorescence detects neuronal morphology and neurite networks; TMRE detects mitochondrial membrane potential; and MEA recordings detect functional changes in neuronal network activity.
Purity & Documentation
-
Data Sheet (287 KB)
-
SDS (788 KB)
- English - EN (788 KB)
- Français - FR (788 KB)
- Deutsch - DE (788 KB)
- Norwegian - NO (788 KB)
- Español - ES (788 KB)
- Swedish - SV (788 KB)
- Italian - IT (788 KB)
- Korean - KR (788 KB)
- Portuguese - PT (788 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Nancy E Todd, et al. Effects of Sevin (Carbaryl Insecticide) on Early Life Stages of Zebrafish (Danio Rerio). Ecotoxicol Environ Saf. 2002 Oct;53(2):267-72. [Content Brief]
[3]. Blevins RD, et al., Effects of carbaryl and dieldrin on the growth,protein content, and phospholipid content of HeLa cells. J Agric Food Chem. 1975 May-Jun;23(3):377-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbaryl-d7 Related Classifications
HY-B1315S1 Related Classifications
Powered by Bioz