100041-05-2
Chemical Structure
Flazin
- CAS No.: 100041-05-2
- Formula:C17H12N2O4
- Molecular Weight:308.29
IUPAC Name: 1-(5-(hydroxymethyl)furan-2-yl)-9H-pyrido[3,4-b]indole-3-carboxylic acid
InChIKey: USBWYUYKHHILLZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C(C3=CC=C(CO)O3)=N1)NC4=C2C=CC=C4)O
Biological Activity: Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor[1][2][3].
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Flazin | 99.64% | Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor. | ||||||||||||||||||||
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- [1]. Seong SH, et al. Discovery of Flazin, an Alkaloid Isolated from Cherry Tomato Juice, As a Novel Non-Enzymatic Protein Glycation Inhibitor viain Vitro and in Silico Studies. J Agric Food Chem. 2021 Mar 31;69(12):3647-3657. [Content Brief]
- [2]. Wu X, et al. Flazin as a Lipid Droplet Regulator against Lipid Disorders. Nutrients. 2022 Apr 3;14(7):1501. [Content Brief]
- [3]. Li H, et al. Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor. J Agric Food Chem. 2016 Jun 15;64(23):4725-34. [Content Brief]
Keywords
