1008768-41-9
1008768-41-9
Chemical Structure
TEAD-IN-8
- CAS No.: 1008768-41-9
- Formula:C26H33N3O3
- Molecular Weight:435.56
InChIKey: LWLAYULJAJMPKG-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4
Biological Activity: TEAD-IN-8 is a novel TEAD inhibitor, which potently and specifically inhibits TEAD-YAP transcriptional activities. TM2, alone or in combination with MEK inhibitors, exhibits potent antiproliferative effects in YAP-dependent cancer cells[1].
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TEAD-IN-8 | 99.84% | TEAD-IN-8 is a novel TEAD inhibitor, which potently and specifically inhibits TEAD-YAP transcriptional activities. TM2, alone or in combination with MEK inhibitors, exhibits potent antiproliferative effects in YAP-dependent cancer cells. | ||||||||||||||||||||
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Structural Analogs
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HY-141842GLP-1R modulator L7-028 -
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HY-126749VUF14738 -
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HY-106936Mazapertine -
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HY-50709RA939572 (Standard) -
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HY-18013JNJ-40355003 -
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HY-108139F-14258 -
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HY-119344MS37452 -
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HY-28325AMC-04 -
Similarity Score 0.52
HY-161766L687 -
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