TEAD-IN-8

Cat. No.: HY-163173 Purity: 99.84%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

TEAD-IN-8 is a novel TEAD inhibitor, which potently and specifically inhibits TEAD-YAP transcriptional activities. TM2, alone or in combination with MEK inhibitors, exhibits potent antiproliferative effects in YAP-dependent cancer cells.

For research use only. We do not sell to patients.

TEAD-IN-8 Chemical Structure

CAS No. : 1008768-41-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All YAP Isoform Specific Products:

View All Isoforms

YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

YAP/TAZ-TEAD

Molecular Weight

435.56

Formula

C₂₆H₃₃N₃O₃

CAS No.

1008768-41-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (229.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2959 mL	11.4795 mL	22.9590 mL
5 mM	0.4592 mL	2.2959 mL	4.5918 mL
10 mM	0.2296 mL	1.1479 mL	2.2959 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (244 KB) HNMR (267 KB) LCMS (338 KB) Elemental Analysis Report (102 KB)

Handling Instructions (2659 KB)

References

[1]. Hu L, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2959 mL	11.4795 mL	22.9589 mL	57.3974 mL
	5 mM	0.4592 mL	2.2959 mL	4.5918 mL	11.4795 mL
	10 mM	0.2296 mL	1.1479 mL	2.2959 mL	5.7397 mL
	15 mM	0.1531 mL	0.7653 mL	1.5306 mL	3.8265 mL
	20 mM	0.1148 mL	0.5740 mL	1.1479 mL	2.8699 mL
	25 mM	0.0918 mL	0.4592 mL	0.9184 mL	2.2959 mL
	30 mM	0.0765 mL	0.3826 mL	0.7653 mL	1.9132 mL
	40 mM	0.0574 mL	0.2870 mL	0.5740 mL	1.4349 mL
	50 mM	0.0459 mL	0.2296 mL	0.4592 mL	1.1479 mL
	60 mM	0.0383 mL	0.1913 mL	0.3826 mL	0.9566 mL
	80 mM	0.0287 mL	0.1435 mL	0.2870 mL	0.7175 mL
	100 mM	0.0230 mL	0.1148 mL	0.2296 mL	0.5740 mL

TEAD-IN-8 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TEAD-IN-81008768-41-9YAPYes-associated proteinTEAD inhibitorMEK inhibitorTEAD-YAPantiproliferativeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

TEAD-IN-8

TEAD-IN-8 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All YAP Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator