2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor 5-HT Receptor Adrenergic Receptor
  4. Mazapertine

Mazapertine is an orally active antipsychotic agent. M azapertine antagonizes to dopamine D2/3/4 receptors (Ki values < 3 nM) and also strongly binds to serotonin 5-HT1A receptor (Ki =1.7 nM) and α1-adrenergic receptor (Ki = 1.3 nM). Mazapertine can be used for the research of neurological disease.

For research use only. We do not sell to patients.

Mazapertine

Mazapertine Chemical Structure

CAS No. : 134208-17-6

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Mazapertine Related Antibodies

Top Publications Citing Use of Products

View All Dopamine Receptor Isoform Specific Products:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

View All 5-HT Receptor Isoform Specific Products:

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mazapertine is an orally active antipsychotic agent. M azapertine antagonizes to dopamine D2/3/4 receptors (Ki values < 3 nM) and also strongly binds to serotonin 5-HT1A receptor (Ki =1.7 nM) and α1-adrenergic receptor (Ki = 1.3 nM). Mazapertine can be used for the research of neurological disease[1].

IC50 & Target[1]

D2 Receptor

<3 nM (Ki)

D3 Receptor

<3 nM (Ki)

D4 Receptor

<3 nM (Ki)

α1-adrenergic receptor

1.3 nM (Ki)

5-HT1A Receptor

1.7 nM (Ki)

Molecular Weight

421.58

Formula

C26H35N3O2
CAS No.
Appearance

Oil

Color

Yellow to brown

SMILES

CC(C)OC1=C(N2CCN(CC3=CC(C(N4CCCCC4)=O)=CC=C3)CC2)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (237.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3720 mL 11.8601 mL 23.7203 mL
5 mM 0.4744 mL 2.3720 mL 4.7441 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3720 mL 11.8601 mL 23.7203 mL 59.3007 mL
5 mM 0.4744 mL 2.3720 mL 4.7441 mL 11.8601 mL
10 mM 0.2372 mL 1.1860 mL 2.3720 mL 5.9301 mL
15 mM 0.1581 mL 0.7907 mL 1.5814 mL 3.9534 mL
20 mM 0.1186 mL 0.5930 mL 1.1860 mL 2.9650 mL
25 mM 0.0949 mL 0.4744 mL 0.9488 mL 2.3720 mL
30 mM 0.0791 mL 0.3953 mL 0.7907 mL 1.9767 mL
40 mM 0.0593 mL 0.2965 mL 0.5930 mL 1.4825 mL
50 mM 0.0474 mL 0.2372 mL 0.4744 mL 1.1860 mL
60 mM 0.0395 mL 0.1977 mL 0.3953 mL 0.9883 mL
80 mM 0.0297 mL 0.1483 mL 0.2965 mL 0.7413 mL
100 mM 0.0237 mL 0.1186 mL 0.2372 mL 0.5930 mL
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Mazapertine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mazapertine134208-17-6Dopamine Receptor5-HT ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta ReceptorInhibitorinhibitorinhibit

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