102783-53-9
Chemical Structure
2,3-Diphospho-D-glyceric acid pentasodium salt
Synonym(s): 2,3-DPG pentasodium salt
- CAS No.: 102783-53-9
- Formula:C3H3Na5O10P2
- Molecular Weight:375.95
IUPAC Name: sodium (R)-2,3-bis(phosphonatooxy)propanoate
InChIKey: KPRMRMXBVAUXKZ-WXQRJNCRSA-I
SMILES: O=P(O[Na])(O[Na])OC[C@H](C(O[Na])=O)OP(O[Na])(O[Na])=O
Biological Activity:
2,3-Diphospho-D-glyceric acid (2,3-DPG) pentasodium salt is a hemoglobin binder and vascular calcification inhibitor that reduces the oxygen affinity of hemoglobin. 2,3-Diphospho-D-glyceric acid pentasodium salt also specifically delays the transformation of colloidal calciprotein particles into crystalline forms, thereby effectively inhibiting vascular smooth muscle cell calcification without affecting the normal formation of osteoid nodules in osteoblast-like cells. 2,3-Diphospho-D-glyceric acid pentasodium salt shows no cytotoxicity to tested cell lines and only weakly interferes with β-hematin formation mediated by glyceryl monopalmitate. 2,3-Diphospho-D-glyceric acid pentasodium salt can be used to study the pathological mechanisms of vascular calcification and malaria-related conditions[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2,3-Diphospho-D-glyceric acid pentasodium salt | 95.0% | 2,3-Diphospho-D-glyceric acid (2,3-DPG) pentasodium salt is a hemoglobin binder and vascular calcification inhibitor that reduces the oxygen affinity of hemoglobin. 2,3-Diphospho-D-glyceric acid pentasodium salt also specifically delays the transformation of colloidal calciprotein particles into crystalline forms, thereby effectively inhibiting vascular smooth muscle cell calcification without affecting the normal formation of osteoid nodules in osteoblast-like cells. 2,3-Diphospho-D-glyceric acid pentasodium salt shows no cytotoxicity to tested cell lines and only weakly interferes with β-hematin formation mediated by glyceryl monopalmitate. 2,3-Diphospho-D-glyceric acid pentasodium salt can be used to study the pathological mechanisms of vascular calcification and malaria-related conditions. |
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- [1]. Kharaghani D, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668.
- [2]. Ambele MA, et al. Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition. Malar J. 2012;11:337. Published 2012 Oct 8. [Content Brief]
