1035638-91-5
1035638-91-5
Chemical Structure
PF-6274484
- CAS No.: 1035638-91-5
- Formula:C18H14ClFN4O2
- Molecular Weight:372.78
IUPAC Name: N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide
InChIKey: TUYDDIWQXWTNSW-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1OC)=O
Biological Activity: PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-6274484 | 98.76% | PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively. | ||||||||||||||||||||
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References
Keywords
