1035638-91-5
1035638-91-5
Chemical Structure
PF-6274484
- CAS No.: 1035638-91-5
- Formula:C18H14ClFN4O2
- Molecular Weight:372.78
IUPAC Name: N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide
InChIKey: TUYDDIWQXWTNSW-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1OC)=O
Biological Activity: PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively[1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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PF-6274484 | 98.76% | PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.91
HY-Z4779Dacomitinib impurity 4 -
Similarity Score 0.87
HY-135727PF-6422899 -
Similarity Score 0.80
HY-133780Afatinib impurity 11 -
Similarity Score 0.79
HY-164503Neptinib -
Similarity Score 0.78
HY-13272Dacomitinib -
Similarity Score 0.77
HY-118263Dacomitinib hydrate -
Similarity Score 0.77
HY-138916PF-06672131 -
Similarity Score 0.77
HY-152852Mefatinib free base -
Similarity Score 0.75
HY-10367Canertinib -
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