1041434-82-5
Chemical Structure
Peramivir trihydrate
Synonym(s): RWJ 270201 trihydrate; BCX 1812 trihydrate
- CAS No.: 1041434-82-5
- Formula:C15H34N4O7
- Molecular Weight:382.45
IUPAC Name: (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentane-1-carboxylic acid trihydrate
InChIKey: RFUCJKFZFXNIGB-ZBBHRWOZSA-N
SMILES: O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O.[H]O.[H]O.[H]O
Biological Activity: Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Peramivir trihydrate | 98.30% | Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. | ||||||||||||||||||||
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Peramivir trihydrate (Standard) | 99.84% | Peramivir (trihydrate) (Standard) is the analytical standard of Peramivir (trihydrate). This product is intended for research and analytical applications. Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. | ||||||||||||||||||||
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Similarity Score 0.96
HY-17015APeramivir -
Similarity Score 0.68
HY-W131701RMethyl (1S,2S,3R,4R)-3-((R)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate (Standard) -
Similarity Score 0.66
HY-105395BCX-1898 -
Similarity Score 0.48
HY-121348Ficellomycin -
Similarity Score 0.47
HY-N7529Siastatin B -
Similarity Score 0.46
HY-15282E-64 -
Similarity Score 0.46
HY-W014130AN-Acetyl-L-arginine dihydrate -
Similarity Score 0.46
HY-P0143Leucylarginylproline -
Similarity Score 0.45
HY-P4483H-Pro-Arg-OH -
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References
- [1]. Zhang C, et al. Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects [J]. Frontiers in Immunology, 2022, 13: 856327. [Content Brief]
- [2]. Pascua P N Q, et al. Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection [J]. Scientific reports, 2017, 7(1): 7345. [Content Brief]
- [3]. Alame M M, et al.. Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections [J]. Frontiers in microbiology, 2016, 7: 450. [Content Brief]
