111113-73-6
Chemical Structure
8-Deazahomofolic acid
- CAS No.: 111113-73-6
- Formula:C21H22N6O6
- Molecular Weight:454.44
IUPAC Name: (4-((2-(2-amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
InChIKey: NHMPJFQQAWJNNS-HNNXBMFYSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCCC2=CC=C(C3=N2)NC(N)=NC3=O)C=C1)=O
Biological Activity:
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors[1].
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8-Deazahomofolic acid | 8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors. |
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Keywords
