112294-81-2
Chemical Structure
Sulopenem sodium
Synonym(s): CP-70429 sodium
- CAS No.: 112294-81-2
- Formula:C12H14NNaO5S3
- Molecular Weight:371.43
InChIKey: MRHMJKHFABHUKB-LQUSNCHHSA-M
SMILES: O=C(C(N12)=C(S[C@@H](CC3)C[S@@]3=O)S[C@]2([H])[C@@H]([C@H](O)C)C1=O)O[Na]
Biological Activity: Sulopenem (sodium)(CP-70429 (sodium)) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia[1][2][3].
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Sulopenem sodium | Sulopenem (sodium)(CP-70429 (sodium)) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia. | |||||||||||||||||||||
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- [1]. Karlowsky JA, et al. In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli. Antimicrob Agents Chemother. 2018;63(1):e01832-18. Published 2018 Dec 21. [Content Brief]
- [2]. Minamimura M, et al. In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic. Antimicrob Agents Chemother. 1993;37(7):1547-1551. [Content Brief]
- [3]. Nagashima M, et al. In vitro and in vivo activities of sulopenem compared with those of imipenem and cephalosporins. Jpn J Antibiot. 1996;49(4):303-323. [Content Brief]
Keywords
