112649-21-5
Chemical Structure
Garcinone E
- CAS No.: 112649-21-5
- Formula:C28H32O6
- Molecular Weight:464.55
IUPAC Name: 2,3,6,8-tetrahydroxy-1,4,7-tris(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
InChIKey: WVJYEKGQSBGNRP-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC3=C1C(O)=C(C/C=C(C)\C)C(O)=C3)C(C/C=C(C)\C)=C(O)C(O)=C2C/C=C(C)\C
Biological Activity: Garcinone E is a xanthone natural product that exerts antioxidant, anti-inflammatory, antitumor, and immunomodulatory activities by inhibiting JNK, TNF-α, NF-κB, and FAS, and enhancing Nrf2 signaling pathways. Garcinone E can be used in research on autoimmune hepatitis, obesity, and various cancers (including breast cancer, colorectal cancer, cervical cancer, liver cancer, lung cancer, and gastric cancer)[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Garcinone E | 98.19% | Garcinone E is a xanthone natural product that exerts antioxidant, anti-inflammatory, antitumor, and immunomodulatory activities by inhibiting JNK, TNF-α, NF-κB, and FAS, and enhancing Nrf2 signaling pathways. Garcinone E can be used in research on autoimmune hepatitis, obesity, and various cancers (including breast cancer, colorectal cancer, cervical cancer, liver cancer, lung cancer, and gastric cancer). | ||||||||||||||||||||
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References
- [1]. Mohamed GA, et al. Garcinone E Mitigates Oxidative Inflammatory Response and Protects against Experimental Autoimmune Hepatitis via Modulation of Nrf2/HO-1, NF-κB and TNF-α/JNK Axis. Nutrients. 2022 Dec 21;15(1):16.
- [2]. Yang L, et al. Garcinone-E exhibits anticancer effects in HeLa human cervical carcinoma cells mediated via programmed cell death, cell cycle arrest and suppression of cell migration and invasion. AMB Express. 2020 Jul 16;10(1):126. [Content Brief]
- [3]. Liang Y, et al. Inhibitory effects of garcinone E on fatty acid synthase. RSC advances. 2018 Feb 19;8(15):8112-8117.
- [4]. Nie X, et al. Garcinone E suppresses breast cancer growth and metastasis by modulating tumor-associated macrophages polarization via STAT6 signaling. Phytotherapy research : PTR. 2023 Oct;37(10):4442-4456.
- [5]. Li R, et al. Garcinone E triggers apoptosis and cell cycle arrest in human colorectal cancer cells by mediating a reactive oxygen species-dependent JNK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun;162:114617.
- [6]. Wei D, et al. Identification of natural compound garcinone E as a novel autophagic flux inhibitor with anticancer effect in nasopharyngeal carcinoma cells. Pharmaceutical biology. 2023 Dec;61(1):839-857.
