1146594-87-7
Chemical Structure
JNJ-40418677
- CAS No.: 1146594-87-7
- Formula:C26H22F6O2
- Molecular Weight:480.44
IUPAC Name: (S)-2-(4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-5'-yl)-4-methylpentanoic acid
InChIKey: RQOWDDLKGBMJFX-QHCPKHFHSA-N
SMILES: CC(C)C[C@@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=CC(C3=CC=C(C=C3)C(F)(F)F)=C1)C(O)=O
Biological Activity: JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNJ-40418677 | 99.48% | JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research. | ||||||||||||||||||||
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Similarity Score 1.00
HY-100604AR(R)-JNJ-40418677 (Standard) -
Similarity Score 0.59
![3,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w456351.gif)
HY-W4563513,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid -
Similarity Score 0.57
HY-181489SARS-CoV-2 3CLpro-IN-35 -
Similarity Score 0.57
HY-13967AMG 837 -
Similarity Score 0.56
![2',5'-Bis(trifluoromethyl)-[1,1':4',1"-terphenyl]-4,4"-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w112628.gif)
HY-W1126282',5'-Bis(trifluoromethyl)-[1,1':4',1"-terphenyl]-4,4"-dicarboxylic acid -
Similarity Score 0.56
![5'-Methyl-[1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075461.gif)
HY-W0754615'-Methyl-[1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid -
Similarity Score 0.56
![[1,1':3',1''-Terphenyl]-4,4'',5'-tricarboxylicacid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w112944.gif)
HY-W112944[1,1':3',1''-Terphenyl]-4,4'',5'-tricarboxylicacid -
Similarity Score 0.56
HY-117521EVP-0015962 -
Similarity Score 0.55
HY-13967AAMG 837 sodium salt -
Explore the MedChemAI to find more analogs
![3,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w456351.gif)
![2',5'-Bis(trifluoromethyl)-[1,1':4',1"-terphenyl]-4,4"-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w112628.gif)
![5'-Methyl-[1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075461.gif)
![[1,1':3',1''-Terphenyl]-4,4'',5'-tricarboxylicacid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w112944.gif)
References
- [1]. Van Broeck B, et al. Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011 May;163(2):375-89. [Content Brief]
- [2]. Harrie J.M. Gijsen, et al. Chapter Five - Secretase Inhibitors and Modulators as a Disease-Modifying Approach Against Alzheimer's Disease. Annu Rep Med Chem. 2012. 47:55-69.
- [3]. Samrat SK, et al. Antiviral Agents against Flavivirus Protease: Prospect and Future Direction. Pathogens. 2022 Feb 25;11(3):293. [Content Brief]
