1146594-87-7
1146594-87-7
Chemical Structure
JNJ-40418677
- CAS No.: 1146594-87-7
- Formula:C26H22F6O2
- Molecular Weight:480.44
IUPAC Name: (S)-2-(4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-5'-yl)-4-methylpentanoic acid
InChIKey: RQOWDDLKGBMJFX-QHCPKHFHSA-N
SMILES: CC(C)C[C@@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=CC(C3=CC=C(C=C3)C(F)(F)F)=C1)C(O)=O
Biological Activity: JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNJ-40418677 | 99.48% | JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research. | ||||||||||||||||||||
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References
- [1]. Van Broeck B, et al. Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011 May;163(2):375-89. [Content Brief]
- [2]. Harrie J.M. Gijsen, et al. Chapter Five - Secretase Inhibitors and Modulators as a Disease-Modifying Approach Against Alzheimer's Disease. Annu Rep Med Chem. 2012. 47:55-69.
- [3]. Samrat SK, et al. Antiviral Agents against Flavivirus Protease: Prospect and Future Direction. Pathogens. 2022 Feb 25;11(3):293. [Content Brief]
