116162-16-4
116162-16-4
Chemical Structure
NE58027
- CAS No.: 116162-16-4
- Formula:C7H17NO7P2
- Molecular Weight:289.16
InChIKey: GKUBJNUBGKBXKR-UHFFFAOYSA-N
SMILES: O=P(O)(C(CC1NCCCC1)(P(O)(O)=O)O)O
Biological Activity: NE58027 is a farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 values of 591.6 nM and 13.7 nM against the human target. NE58027 is an analog of Risedronic acid (HY-B0148). NE58027 causes downstream accumulation of isopentenyl pyrophosphate and the cytotoxic ATP analog ApppI in human breast cancer cells. NE58027 can be used in breast cancer-related research[1][2].
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NE58027 | NE58027 is a farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 values of 591.6 nM and 13.7 nM against the human target. NE58027 is an analog of Risedronic acid (HY-B0148). NE58027 causes downstream accumulation of isopentenyl pyrophosphate and the cytotoxic ATP analog ApppI in human breast cancer cells. NE58027 can be used in breast cancer-related research. | |||||||||||||||||||||
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References
- [1]. Fernández D, et al. Human farnesyl pyrophosphate synthase inhibition by nitrogen bisphosphonates: a 3D-QSAR study. Journal of Computer-Aided Molecular Design, 2013, 27: 739-754.
- [2]. Räikkönen J, et al. Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. Biochemical and biophysical research communications. 2011 Apr 22;407(4):663-7. [Content Brief]
