118997-92-5
Chemical Structure
Kalmanol
- CAS No.: 118997-92-5
- Formula:C20H34O6
- Molecular Weight:370.48
IUPAC Name: (2aR,2a1R,3R,4aS,6R,6aR,8S,9aS,10R,10aR)-3,7,7,10-tetramethyltetradecahydrocyclopenta[5,6]cycloocta[1,2,3-cd]pentalene-3,4a,6,6a,8,10-hexaol
InChIKey: PNXZEOYIDGRIFH-WHXJEJCNSA-N
SMILES: O[C@@]12[C@@]3([H])[C@](CC[C@@]3([H])[C@](O)(C2)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C1)O)(C(C)([C@H](C4)O)C)O)C
Biological Activity: Kalmanol is a kalmane-type diterpenoid found in Rhododendri Mollis Flos and the leaves of Schinus terebinthifolius. Kalmanol is a state-dependent inhibitor of NaV1.4 channels, and upon binding to inactivated channels, it shifts the fast inactivation curve toward hyperpolarized potentials. Kalmanol exhibits analgesic activity and is used in pain-related research[1][2][3][4][5].
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Kalmanol | Kalmanol is a kalmane-type diterpenoid found in Rhododendri Mollis Flos and the leaves of Schinus terebinthifolius. Kalmanol is a state-dependent inhibitor of NaV1.4 channels, and upon binding to inactivated channels, it shifts the fast inactivation curve toward hyperpolarized potentials. Kalmanol exhibits analgesic activity and is used in pain-related research. | |||||||||||||||||||||
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References
- [1]. Guo XH, et al. [Toxicity mechanism of Rhododendri Mollis Flos: based on serum metabolomics and network toxicology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Apr;47(7):1932-1941.
- [2]. Tsuruyama T, et al. Bioinspired Chemical Transformations of Grayanotoxin III to Kalmanol, -Rhodomollone, and Rhodomolleins XXIII and XXIV. Journal of natural products. 2026 Jan 23;89(1):161-169.
- [3]. Feng Y, et al. Discovery of kalmane diterpenoids as potent analgesics from the flowers of Rhododendron dauricum. Chinese Journal of Chemistry. 2022 May 1;40(9):1019-27.
- [4]. Ma T, et al. Total Synthesis of (+)-Kalmanol. Angewandte Chemie (International ed. in English). 2024 Oct 14;63(42):e202407215.
- [5]. Nguyen VK, et al. Free and bound phenolic extracts of Schinus terebinthifolius leaves: phytochemical profiling and in vitro–in silico bioactivity investigations. Natural Product Research. 2026 Mar 6:1-6.
