1227045-76-2
Chemical Structure
AK-778-XXMU
- CAS No.: 1227045-76-2
- Formula:C22H17ClN2O3
- Molecular Weight:392.83
IUPAC Name: 1-(3-chlorobenzyl)-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one
InChIKey: JJOIKBZRLCEZOR-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=N1)CC2(C(N(C3=C2C=CC=C3)CC4=CC=CC(Cl)=C4)=O)O
Biological Activity: AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma[1].
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AK-778-XXMU | 99.96% | AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma. | ||||||||||||||||||||
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Keywords
