1227045-76-2

AK-778-XXMU Chemical Structure
1227045-76-2

Chemical Structure

AK-778-XXMU

  • CAS No.: 1227045-76-2
  • Formula:C22H17ClN2O3
  • Molecular Weight:392.83

IUPAC Name: 1-(3-chlorobenzyl)-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one

InChIKey: JJOIKBZRLCEZOR-UHFFFAOYSA-N

SMILES: O=C(C1=CC=CC=N1)CC2(C(N(C3=C2C=CC=C3)CC4=CC=CC(Cl)=C4)=O)O

Biological Activity: AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma[1].

Cat. No. Product Name Purity Description Pricing
HY-144707 		AK-778-XXMU 99.96% AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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Keywords