NF-κB-IN-3
Based on 1 publication(s) in Google Scholar
NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC50 of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent.
For research use only. We do not sell to patients.
- CAS No.: 1873311-82-0
- Formula: C24H18ClF3N2O2
- Molecular Weight:458.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) NF-κB-IN-3
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Biological Activity
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NF-κB 0.70 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ACHN | GI50 |
0.526 μM
Compound: 6g
|
Cytotoxicity against human ACHN cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human ACHN cells after 72 hrs by sulforhodamine B assay
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[PMID: 27096046] |
| HCT-15 | GI50 |
0.797 μM
Compound: 6g
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Cytotoxicity against human HCT15 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HCT15 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 27096046] |
| MDA-MB-231 | GI50 |
0.288 μM
Compound: 6g
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
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[PMID: 27096046] |
| NCI-H23 | GI50 |
0.292 μM
Compound: 6g
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Cytotoxicity against human NCI-H23 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H23 cells after 72 hrs by sulforhodamine B assay
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[PMID: 27096046] |
| NUGC-3 | GI50 |
0.754 μM
Compound: 6g
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Cytotoxicity against human NUGC3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human NUGC3 cells after 72 hrs by sulforhodamine B assay
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[PMID: 27096046] |
| PC-3 | GI50 |
0.729 μM
Compound: 6g
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Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 27096046] |
| RAW264.7 | IC50 |
0.7 μM
Compound: 6g
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Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
|
[PMID: 27096046] |
Chemical Information
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CAS No. 1873311-82-0
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Molecular Weight 458.86
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Formula C24H18ClF3N2O2
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SMILES
O=C(C1CCC2=CC=CC=C2N1C(C3=CC=CC(Cl)=C3)=O)NC4=CC=CC=C4C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Cell Mol Med
Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4/NF-κB/IL-6/STAT3 Signalling Cascade. [Abstract]2026 Feb;30(3):e71050. PMID: 41645802
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)