country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-144744

Copy Link Print Information

NF-κB-IN-3

Name: NF-κB-IN-3
Brand: MedChemExpress
SKU: HY-144744
Availability: PreOrder

1 Cited Publications

Avis client

Based on 1 publication(s) in Google Scholar

NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC₅₀ of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1873311-82-0
Formule: C₂₄H₁₈ClF₃N₂O₂
Masse moléculaire:458.86

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NF-κB-IN-3 Chemical Structure

CAS No.: 1873311-82-0

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC₅₀ of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent^[1].

IC₅₀ & Target

NF-κB

0.70 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
ACHN	GI₅₀	0.526 μM Compound: 6g	Cytotoxicity against human ACHN cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human ACHN cells after 72 hrs by sulforhodamine B assay	[PMID: 27096046]
HCT-15	GI₅₀	0.797 μM Compound: 6g	Cytotoxicity against human HCT15 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human HCT15 cells after 72 hrs by sulforhodamine B assay	[PMID: 27096046]
MDA-MB-231	GI₅₀	0.288 μM Compound: 6g	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay	[PMID: 27096046]
NCI-H23	GI₅₀	0.292 μM Compound: 6g	Cytotoxicity against human NCI-H23 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H23 cells after 72 hrs by sulforhodamine B assay	[PMID: 27096046]
NUGC-3	GI₅₀	0.754 μM Compound: 6g	Cytotoxicity against human NUGC3 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human NUGC3 cells after 72 hrs by sulforhodamine B assay	[PMID: 27096046]
PC-3	GI₅₀	0.729 μM Compound: 6g	Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay	[PMID: 27096046]
RAW264.7	IC₅₀	0.7 μM Compound: 6g	Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay	[PMID: 27096046]

Chemical Information

CAS No. 1873311-82-0
Masse moléculaire 458.86
Formule C₂₄H₁₈ClF₃N₂O₂
SMILES

O=C(C1CCC2=CC=CC=C2N1C(C3=CC=CC(Cl)=C3)=O)NC4=CC=CC=C4C(F)(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All

Sort by:

Journal Impact Factor

J Cell Mol Med

Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4/NF-κB/IL-6/STAT3 Signalling Cascade. [Abstract]

2026 Feb;30(3):e71050. PMID: 41645802

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sim S, et al. Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway. Bioorg Med Chem. 2021 Sep 15;46:116371. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

NF-κB-IN-3

1 Cited Publications

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

NF-κB-IN-3

Publications Citing Use of MedChemExpress (MCE) NF-κB-IN-3

Voir tous les produits spécifiques à Isoform NF-κB