123702-96-5
Chemical Structure
2,2′,4,4′-Tetrahydroxychalcone
- CAS No.: 123702-96-5
- Formula:C15H12O5
- Molecular Weight:272.25
InChIKey: ZWTDXYUDJYDHJR-QHHAFSJGSA-N
SMILES: OC(C=C(C=C1)O)=C1/C=C/C(C2=C(C=C(C=C2)O)O)=O
Biological Activity: 2,2′,4,4′-Tetrahydroxychalcone (Compound 18) is a selective and potent BACE1 inhibitor with an IC50 of 0.62 μM. 2,2′,4,4′-Tetrahydroxychalcone is a derivative of Isoliquiritigenin (HY-N0102) found in Glycyrrhiza uralensis. 2,2′,4,4′-Tetrahydroxychalcone can block the β-cutting step of amyloid precursor protein (APP), thereby reducing the production of β-amyloid (Aβ) peptide. 2,2′,4,4′-Tetrahydroxychalcone can be used for research of Alzheimer’s disease[1].
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2,2′,4,4′-Tetrahydroxychalcone | 2,2′,4,4′-Tetrahydroxychalcone (Compound 18) is a selective and potent BACE1 inhibitor with an IC50 of 0.62 μM. 2,2′,4,4′-Tetrahydroxychalcone is a derivative of Isoliquiritigenin (HY-N0102) found in Glycyrrhiza uralensis. 2,2′,4,4′-Tetrahydroxychalcone can block the β-cutting step of amyloid precursor protein (APP), thereby reducing the production of β-amyloid (Aβ) peptide. 2,2′,4,4′-Tetrahydroxychalcone can be used for research of Alzheimer’s disease. | |||||||||||||||||||||
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Keywords
