1246816-98-7
Chemical Structure
Raltegravir-d3 potassium
Synonym(s): MK 0518-d3 potassium
- CAS No.: 1246816-98-7
- Formula:C20H18D3FKN6O5
- Molecular Weight:486.53
IUPAC Name: N-(2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide, potassium salt
InChIKey: NLDVPINGTPMESH-NXIGQQGZSA-N
SMILES: O=C(C1=NN=C(O1)C)NC(C)(C2=NC(C(NCC3=CC=C(C=C3)F)=O)=C(C(N2C([2H])([2H])[2H])=O)O)C.[K]
Biological Activity: Raltegravir-d3 (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection[1][2].
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Raltegravir-d3 potassium | Raltegravir-d3 (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. | |||||||||||||||||||||
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Raltegravir potassium (Standard) | ≥98% | Raltegravir (potassium) (Standard) is the analytical standard of Raltegravir (potassium). This product is intended for research and analytical applications. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. | ||||||||||||||||||||
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Raltegravir-13C,d3 potassium | Raltegravir-13C,d3 potassium is 13C labeled Raltegravir potassium (HY-10353A). Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. | |||||||||||||||||||||
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Raltegravir-d4 potassium | Raltegravir-d4 (potassium) (MK 0518-d4 (potassium)) is deuterium labeled Raltegravir (potassium). Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. | |||||||||||||||||||||
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Raltegravir potassium | 99.82% | Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. | ||||||||||||||||||||
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Similarity Score 0.90
HY-10353BRaltegravir sodium -
Similarity Score 0.88
HY-10353RRaltegravir (Standard) -
Similarity Score 0.64
HY-10353SRaltegravir-d4 -
Similarity Score 0.63
HY-10353S1Raltegravir-d6 -
Similarity Score 0.59
HY-43347SBenzyl 2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-ylcarbamate-d3 -
Similarity Score 0.50
HY-13269RBMS-707035 (Standard) -
Similarity Score 0.45
HY-W005294SMethyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate-d3 -
Similarity Score 0.44
HY-16907AGSK-364735 potassium -
Similarity Score 0.44
HY-16907BGSK-364735 sodium -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Hare, S., et al., Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A, 2010. 107(46): p. 20057-62. [Content Brief]
