124796-41-4
Chemical Structure
5-Fluoromethylornithine dihydrochloride
Synonym(s): 5-FMOrn dihydrochloride
- CAS No.: 124796-41-4
- Formula:C6H15Cl2FN2O2
- Molecular Weight:237.10
IUPAC Name: 2,5-diamino-6-fluorohexanoic acid dihydrochloride
InChIKey: ZOZPMKYVFZNAHT-UHFFFAOYSA-N
SMILES: NC(CCC(N)CF)C(O)=O.[H]Cl.[H]Cl
Biological Activity: 5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) is an orally active and blood-brain barrier-penetrant irreversible inhibitor of ornithine aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride competes with ornithine at the OAT active site and acts as a poor substrate for ornithine decarboxylase (ODC), competitively reducing ornithine decarboxylation, elevating tissue ornithine, and thereby affecting polyamine metabolism. 5-Fluoromethylornithine dihydrochloride attenuates Thioacetamide (HY-Y0698)-induced acute liver injury-related pathological changes. 5-Fluoromethylornithine dihydrochloride is used in research on acute liver injury and hyperammonemia[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Fluoromethylornithine dihydrochloride | 99.08% | 5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) is an orally active and blood-brain barrier-penetrant irreversible inhibitor of ornithine aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride competes with ornithine at the OAT active site and acts as a poor substrate for ornithine decarboxylase (ODC), competitively reducing ornithine decarboxylation, elevating tissue ornithine, and thereby affecting polyamine metabolism. 5-Fluoromethylornithine dihydrochloride attenuates Thioacetamide (HY-Y0698)-induced acute liver injury-related pathological changes. 5-Fluoromethylornithine dihydrochloride is used in research on acute liver injury and hyperammonemia. | ||||||||||||||||||||
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References
- [1]. Seiler N, et al. Inhibition of ornithine aminotransferase by 5-fluoromethylornithine: protection against acute thioacetamide intoxication by elevated tissue ornithine levels. Pharmacology & toxicology. 1992 May;70(5 Pt 1):373-80.
- [2]. Daune G, et al. 5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase. The Biochemical journal. 1988 Jul 15;253(2):481-8. [Content Brief]
- [3]. Ducep J, et al. Inhibition of Ornithine Aminotransferase: A New Target for Therapeutic Intervention. ACS Symposium Series. 1996;10.1021/BK-1996-0639.CH015.
- [4]. Imada S, et al. Short-term post-fast refeeding enhances intestinal stemness via polyamines. Nature. 2024 Sep;633(8031):895-904. [Content Brief]
