125697-91-8
125697-91-8
Chemical Structure
Lavendustin B
- CAS No.: 125697-91-8
- Formula:C21H19NO5
- Molecular Weight:365.38
IUPAC Name: 5-(bis(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
InChIKey: RTYOLBQXFXYMKY-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(N(CC2=CC=CC=C2O)CC3=CC=CC=C3O)=CC=C1O
Biological Activity: Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].
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Lavendustin B | 98.02% | Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases. | ||||||||||||||||||||
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References
- [1]. J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40(3):777-90. [Content Brief]
- [2]. Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683. [Content Brief]
Keywords
