125697-91-8
125697-91-8
Chemical Structure
Lavendustin B
- CAS No.: 125697-91-8
- Formula:C21H19NO5
- Molecular Weight:365.38
IUPAC Name: 5-(bis(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
InChIKey: RTYOLBQXFXYMKY-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(N(CC2=CC=CC=C2O)CC3=CC=CC=C3O)=CC=C1O
Biological Activity: Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lavendustin B | 98.02% | Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-18963RLavendustin A (Standard) -
Similarity Score 0.63
HY-114667Lavendustin C6 -
Similarity Score 0.60
HY-W013857Lavendustin C -
Similarity Score 0.55
HY-W1122975-(Bis(4-carboxybenzyl)amino)-isophthalic acid -
Similarity Score 0.54
![Bis-5-[[(3-carboxyphenyl)methyl]amino]-1,3-benzenedicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586896.gif)
HY-W586896Bis-5-[[(3-carboxyphenyl)methyl]amino]-1,3-benzenedicarboxylic acid -
Similarity Score 0.54
![4,4''-Dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylicacid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w113018.gif)
HY-W1130184,4''-Dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylicacid -
Similarity Score 0.54
![4,4′-[[(4-Carboxyphenyl)imino]bis(methylene)]bis[benzoic acid] Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586874.gif)
HY-W5868744,4′-[[(4-Carboxyphenyl)imino]bis(methylene)]bis[benzoic acid] -
Similarity Score 0.54
HY-116940Sm4 -
Similarity Score 0.54
HY-131515RTri-Salicylic acid (Standard) -
Explore the MedChemAI to find more analogs
![Bis-5-[[(3-carboxyphenyl)methyl]amino]-1,3-benzenedicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586896.gif)
![4,4''-Dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylicacid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w113018.gif)
![4,4′-[[(4-Carboxyphenyl)imino]bis(methylene)]bis[benzoic acid] Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586874.gif)
References
- [1]. J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40(3):777-90. [Content Brief]
- [2]. Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683. [Content Brief]
