1262873-06-2
Chemical Structure
Sepetaprost
Synonym(s): ONO-9054
- CAS No.: 1262873-06-2
- Formula:C26H36F2O6
- Molecular Weight:482.56
IUPAC Name: isopropyl 4-((3S,5aR,6R,7R,8aS)-6-((R,E)-4-(2,5-difluorophenoxy)-3-hydroxybut-1-en-1-yl)-7-hydroxyoctahydro-2H-cyclopenta[b]oxepin-3-yl)butanoate
InChIKey: BKVUSNOUTQMSBE-XCMGCKIWSA-N
SMILES: O=C(OC(C)C)CCC[C@H]1CC[C@@]([C@@H](/C=C/[C@@H](O)COC2=CC(F)=CC=C2F)[C@H](O)C3)([H])[C@@]3([H])OC1
Biological Activity: Sepetaprost (ONO-9054) is a dual agonist of the prostaglandin E3 receptor and prostaglandin F receptor. Sepetaprost reduces intraocular pressure in animal models. Sepetaprost is applicable for research on ocular hypertension and open-angle glaucoma[1][2].
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Sepetaprost | Sepetaprost (ONO-9054) is a dual agonist of the prostaglandin E3 receptor and prostaglandin F receptor. Sepetaprost reduces intraocular pressure in animal models. Sepetaprost is applicable for research on ocular hypertension and open-angle glaucoma. | |||||||||||||||||||||
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- [1]. Suto F, et al. A Novel Dual Agonist of EP3 and FP Receptors for OAG and OHT: Safety, Pharmacokinetics, and Pharmacodynamics of ONO-9054 in Healthy Volunteers. Invest Ophthalmol Vis Sci. 2015;56(13):7963-7970. [Content Brief]
- [2]. Maki K, et al. The Role of EP3 Agonism in Intraocular Pressure-Lowering by Sepetaprost, a Novel Dual Agonist of FP and EP3 Receptors, in Monkeys. J Ocul Pharmacol Ther. 2026;42(3):172-178. [Content Brief]
Keywords
