1263093-79-3
Chemical Structure
DL-AP4 sodium
Synonym(s): 2-Amino-4-phosphonobutyric acid sodium
- CAS No.: 1263093-79-3
- Formula:C4H9NNaO5P
- Molecular Weight:205.08
IUPAC Name: sodium hydrogen (3-amino-3-carboxypropyl)phosphonate
InChIKey: IGWPQOULJIILQQ-UHFFFAOYSA-M
SMILES: OC(C(N)CCP(O)(O[Na])=O)=O
Biological Activity: DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes[1][2].
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DL-AP4 sodium | DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes. | |||||||||||||||||||||
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- [1]. Thomsen C, et al., L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. Eur J Pharmacol. 1992 Nov 2;227(3):361-2. [Content Brief]
- [2]. Dolan RP, et al., Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. Vis Neurosci. 1994 Jan-Feb;11(1):23-32. [Content Brief]
Keywords
