1266548-75-7
Chemical Structure
(E)-Hyzetimibe
Synonym(s): (E)-HS-25
- CAS No.: 1266548-75-7
- Formula:C25H21F2NO3
- Molecular Weight:421.44
IUPAC Name: (3R,4S)-1-(4-fluorophenyl)-3-((E)-3-(4-fluorophenyl)-4-hydroxybut-2-en-1-yl)-4-(4-hydroxyphenyl)azetidin-2-one
InChIKey: HEHHPZYUXSFAPV-GLGQCLCGSA-N
SMILES: OC/C(C1=CC=C(C=C1)F)=C/C[C@@H]2[C@@H](C3=CC=C(C=C3)O)N(C4=CC=C(C=C4)F)C2=O
Biological Activity: (E)-Hyzetimibe ((E)-HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe (HY-107176A), a cholesterol-lowering agent. (E)-Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E)-Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E)-Hyzetimibe can be used for the study of HCV infection[1][2].
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(E)-Hyzetimibe | (E)-Hyzetimibe ((E)-HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe (HY-107176A), a cholesterol-lowering agent. (E)-Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E)-Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E)-Hyzetimibe can be used for the study of HCV infection. | |||||||||||||||||||||
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