127757-45-3
Chemical Structure
Cyclic HPMPC
- CAS No.: 127757-45-3
- Formula:C8H12N3O5P
- Molecular Weight:261.17
IUPAC Name: 4-amino-1-(((5S)-2-hydroxy-2-oxido-1,4,2-dioxaphosphinan-5-yl)methyl)pyrimidin-2(1H)-one
InChIKey: YXQUGSXUDFTPLL-LURJTMIESA-N
SMILES: O=C1N(C=CC(N)=N1)C[C@H](OC2)CO[P]2(O)=O
Biological Activity: Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].
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Cyclic HPMPC | Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model. | |||||||||||||||||||||
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- [1]. Smee DF, et al. Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents. 2004;23(5):430-437. [Content Brief]
- [2]. Bravo FJ, et al. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2006;193(4):591-597. [Content Brief]
Keywords
