129300-27-2
129300-27-2
Chemical Structure
Fabesetron
Synonym(s): FK1052 free base
- CAS. Nr.: 129300-27-2
- Formula:C18H19N3O
- Molecular Weight:293.36
IUPAC Name: (R)-10-methyl-7-((5-methyl-1H-imidazol-4-yl)methyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one
InChIKey: AEKQMJRJRAHOAP-CYBMUJFWSA-N
SMILES: O=C1N2C3=C(C=CC=C3)C(C)=C2CC[C@@H]1CC4=C(NC=N4)C
Biological Activity: Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy[1][2].
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Fabesetron | Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy. | |||||||||||||||||||||
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References
- [1]. M Kadowaki, et al. Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 1993 Jul;266(1):74-80. [Content Brief]
- [2]. Hiroe Nakayama, et al. Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets. J Pharmacol Sci. 2005 Aug;98(4):396-403. [Content Brief]
Keywords
