1301167-87-2
Chemical Structure
JNJ-42259152
- CAS No.: 1301167-87-2
- Formula:C24H23FN4O
- Molecular Weight:402.46
IUPAC Name: 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine
InChIKey: OWEZURWNYQWWNB-UHFFFAOYSA-N
SMILES: CC1=CN=C(C(C)=C1)COC2=CC=C(C=C2)C3=NN(C=C3C4=CC=NC=C4)CCF
Biological Activity: JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases[1].
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JNJ-42259152 | JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases. | |||||||||||||||||||||
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Keywords
