1311275-10-1
Chemical Structure
Hydroxycotinine-d3
- CAS No.: 1311275-10-1
- Formula:C10H9D3N2O2
- Molecular Weight:195.23
InChIKey: XOKCJXZZNAUIQN-IRPRQUBLSA-N
SMILES: O[C@@H](C1=O)C[C@](C2=CN=CC=C2)([H])N1C([2H])([2H])[2H]
Biological Activity: Hydroxycotinine-d3 is the d3-labeled Hydroxycotinine (HY-113239). Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease[1][2].
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Hydroxycotinine-d3 | Hydroxycotinine-d3 is the d3-labeled Hydroxycotinine (HY-113239). Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease. | |||||||||||||||||||||
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rel-Hydroxycotinine-d3 | rel-Hydroxycotinine-d3 is the d3-labeled Hydroxycotinine (HY-113239). Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease. | |||||||||||||||||||||
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Hydroxycotinine | 99.13% | Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease. | ||||||||||||||||||||
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References
- [1]. Zhu M, et al. Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES. Renal failure. 2024 Dec;46(1):2356024.
- [2]. Sanchez M E, et al. The effects of electronic nicotine vapor on voluntary alcohol consumption in female and male C57BL/6 J mice[J]. Drug and alcohol dependence, 2022, 241: 109676.
