131817-86-2
Chemical Structure
CGS 22745
- CAS. Nr.: 131817-86-2
- Formula:C16H18N2O2
- Molecular Weight:270.33
IUPAC Name: (E)-3-(4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-N-hydroxy-N-methylacrylamide
InChIKey: ZPBFSCZQRXZGLG-DHZHZOJOSA-N
SMILES: CC=1N(C2=CC=C(/C=C/C(N(C)O)=O)C=C2)C(C)=CC1
Biological Activity: CGS 22745 is a selective and orally active 5-Lipoxygenase inhibitor. CGS 22745 blocks the conversion of Arachidonic acid (HY-109590) to 5-HETE (HY-113434B) and leukotrienes. CGS 22745 inhibits A23187-stimulated LTB4 (HY-107608) formation in whole blood. CGS 22745 inhibits exudate formation and PMN accumulation in Carrageenan (HY-125474)-induced pleurisy. CGS 22745 can be used for research on inflammatory diseases[1].
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CGS 22745 | CGS 22745 is a selective and orally active 5-Lipoxygenase inhibitor. CGS 22745 blocks the conversion of Arachidonic acid (HY-109590) to 5-HETE (HY-113434B) and leukotrienes. CGS 22745 inhibits A23187-stimulated LTB4 (HY-107608) formation in whole blood. CGS 22745 inhibits exudate formation and PMN accumulation in Carrageenan (HY-125474)-induced pleurisy. CGS 22745 can be used for research on inflammatory diseases. | |||||||||||||||||||||
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