132340-44-4
Chemical Structure
FR 111142
- CAS No.: 132340-44-4
- Formula:C22H34O7
- Molecular Weight:410.50
InChIKey: PBVLBMJXKARLBU-HMEWBVIMSA-N
SMILES: O=C(/C=C/[C@H]([C@H](C)O)O)O[C@H]1CC[C@@]2([C@@]([C@@]3(C)O[C@H]3C/C=C(C)\C)([H])[C@H]1OC)OC2
Biological Activity: FR 111142 is an angiogenesis inhibitor (IC50 = 18.4 μM) and has anti-inflammatory activity (IC50 = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS (HY-D1056)-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer, inflammatory diseases[1][2][3].
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FR 111142 | FR 111142 is an angiogenesis inhibitor (IC50 = 18.4 μM) and has anti-inflammatory activity (IC50 = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS (HY-D1056)-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer, inflammatory diseases. | |||||||||||||||||||||
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- [1]. Lee MS, et al. Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195. J Nat Prod. 2016;79(12):2983-2990. [Content Brief]
- [2]. Otsuka T, et al. A new angiogenesis inhibitor, FR-111142. J Antibiot (Tokyo). 1992 Mar;45(3):348-54. [Content Brief]
- [3]. Harada T, et al. Induction of low-density lipoprotein catabolism in Hep G2 cells by a fungal sesquiterpene ester, FR111142. Biochem Biophys Res Commun. 1998 Oct 29;251(3):830-4 [Content Brief]
Keywords
