A new angiogenesis inhibitor, FR-111142

  • J Antibiot (Tokyo). 1992 Mar;45(3):348-54. doi: 10.7164/antibiotics.45.348.
T Otsuka  1 ,  T Shibata ,  Y Tsurumi ,  S Takase ,  M Okuhara ,  H Terano ,  M Kohsaka ,  H Imanaka
Affiliations
  • 1. Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
PMID: 1374374 DOI: 10.7164/antibiotics.45.348
Abstract

FR-111142 is a new angiogenesis inhibitor produced by a fungus Scolecobasidium arenarium F-2015. FR-111142 inhibited endothelial cell proliferation in vitro and angiogenesis in the growing chick chorioallantoic membrane model in vivo. Further, FR-111142 also suppressed the solid tumor growth in mice.

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